The base not taken
Unfortunately, the world has adopted base two (for computer hardware) and base ten (for most human calculations).
Advantages of base six
Base six has advantages over BaseTwo, BaseFour, BaseEight, BaseTen, and BaseTwelve.
Finger hardware
Base six arithmetic can be done on one's fingers: Each hand can have between 0 and 5 digits up, representing numbers between 00 (base 5+1) and 55 (base 5+1). This is not as efficient as using roman numerals, which can represent numbers between 00 (base 9+1) and 99 (base 9+1). Both are more efficent than most people's finger math, which can only represent numbers between 00 and 10 (base 9+1).
Computer hardware
Hardware could be built with native base six support, but it might require (at the transistor or gate level) a combination of two-state and three-state logic.
A times table in base six:
X | 0 1 2 3 4 5 10 11 12 13 14 15 20
---+--------------------------- ----------------------
Discussion:
You can argue the same - more or less - about any number system.
I don't think that the size and simplicity of the multiplication table are key features of a system. In the end all your candidate systems have multiplication tables that are fairly easy to remember compared to the base 60 system of the babylonians (57*56/2 non-trivial entries). I don't think it is necessary to make it simpler.
And you don't just memorize the entries. The structure and interrelation of the matrix entries tell you something about the numbers (number theoretical properties). I hope children don't just do rote memoization of the table but discover and learn the patterns behind the numbers. At least I did. From this point of view any system with a base composed of more than one prime might be advantageous as it can teach you more number theoretical properties while learning the multiplication tables.
And I didn't even start to argue about the advantages of staying with one system - there have been failed tries...
As far as human-friendly, I propose base 12. Let's look at base divisors:
Base 6: 2, 3, 6
Base 8: 2, 4, 8
Base 10: 2, 5
Base 12: 2, 3, 4, 6
Base 16: 2, 6, 8
Base 30: 2, 3, 5, 6
Base 60: 2, 3, 4, 5, 6
I give higher weights to the lower divisors such that being divisible by 3 is more important than being divisible by 8. 60 would be the hands-down favorite if it wasn't so large. 12 is the best compromise.